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KMID : 1164220060180010029
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Journal of Korean Society for Radiotherapeutic Technology
2006 Volume.18 No. 1 p.29 ~ p.34
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Enact of Glutathione(GSH/GSSG) Contents of Fermented Ginseng on the -irradiated Liver of Mice
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Ko In-Ho
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Abstract
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Purpose: The radioprotective effects of white and fermented ginseng on liver damage induced by -ray were investigated.
Materials and Methods: To one group of ICR male mice were given white(150 mg/kg/day for 7 days, orally) and fermented ginseng(150 mg/kg/day for 7 days, orally) before -ray irradiation. To another group were irradiated by 5 Gy(1.01 Gy/min) dose of -ray. Contrast group were given with saline(0.1 mL). The levels of reduced(GSH) and oxidized(GSSG) glutathione in liver tissue were measured.
Results: In the fermented(150 mg/kg) and white ginseng(150 mg/kg) groups than irradiation group, the GSH levels were significantly increased, but the GSSG levels were significantly decreased. The ratio of GSSG/total GSH was significantly decreased in the fermented(150 mg/kg) and white ginseng(150 mg/kg) groups than irradiation group.
Conclusion: In the fermented(150 mg/kg) groups than white ginseng(150 mg/kg) groups the GSH levels were significantly increased. The radioprotective effects of fermented(150 mg/kg) groups than white ginseng(150 mg/kg) groups were increased.
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KEYWORD
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$^{60}Co\, {\gamma}$-ray, fermented ginseng, glutathione
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